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Their study on sickle cell anemia was the first of many to occur at Hopkins. In 1940, Irving Sherman, a medical student at Johns Hopkins, correctly identified the deoxygenation of hemoglobin in sickle cell patients after he noted refraction patterns characteristic of deoxygenation when light was passed through the protein. The deoxygenation of ...
In 1953 he and a research fellow, Ernest W. Smith, described a simple method of separating the components of hemoglobin on filter paper using electrophoresis, which made hemoglobin analysis far more widely available and facilitated the study and treatment of sickle cell anemia. In his studies of sickle cell anemia he followed some patients for ...
Samuel Charache. Samuel Charache (January 12, 1930 – January 29, 2019) was an American hematologist and professor at Johns Hopkins University. He led the research team that discovered the first effective treatment for sickle cell disease, a painful and sometimes fatal blood disorder that mainly affects people of African ancestry.
Sickle cell disease (SCD), also simply called sickle cell, is a group of hemoglobin-related blood disorders typically inherited. [2] The most common type is known as sickle cell anemia. [2] It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. [2] This leads to a rigid, sickle -like shape under ...
Known for. Sickle cell anemia. Scientific career. Fields. Pathology and hematology. Institutions. University of Tennessee 1929. St. Jude Children's Research Hospital 1962. Lemuel Whitley Diggs (January 8, 1900 – January 8, 1995) was an American pathologist who specialized in sickle cell anemia and hematology.
Born at Wapello, Iowa, in 1889, Mason received a B.S. from University of California, Berkeley, in 1911, and an M.D. from Johns Hopkins University in 1915. As a medical resident at Hopkins in 1922 Mason gave the disease sickle cell anemia its name.
The molecular disease concept put forward in the 1949 paper also became the basis for Linus Pauling's view of evolution. In the 1960s, by which time it had been shown that sickle cell trait confers resistance to malaria and so the gene had both positive and negative effects and demonstrated heterozygote advantage, Pauling suggested that ...
John Burdon Sanderson Haldane FRS (/ ˈhɔːldeɪn /; 5 November 1892 – 1 December 1964 [1][2]), nicknamed "Jack" or "JBS", [3] was a British-Indian scientist who worked in physiology, genetics, evolutionary biology, and mathematics. With innovative use of statistics in biology, he was one of the founders of neo-Darwinism.
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