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Binswanger's disease, also known as subcortical leukoencephalopathy and subcortical arteriosclerotic encephalopathy, [1] is a form of small-vessel vascular dementia caused by damage to the white brain matter. [2] White matter atrophy can be caused by many circumstances including chronic hypertension as well as old age. [3] This disease is ...
Leukoencephalopathy with vanishing white matter; Leukoencephalopathy with neuroaxonal spheroids; Reversible posterior leukoencephalopathy syndrome; Megalencephalic leukoencephalopathy with subcortical cysts. It can also refer to gene MLC1 or Megalencephalic leukoencephalopathy with subcortical cysts 1, a human gene related to the former disease.
While the disease is fatal, the age of onset is a key factor, as infants have a typical life expectancy of 2–8 years, while adults typically live more than a decade after onset. Treatment options are limited, although hematopoietic stem cell transplantations using bone marrow or cord blood seem to help in certain leukodystrophy types, while ...
Brain atrophy from vascular dementia: Specialty: Psychiatry, neurology Symptoms: Cognitive impairment, short-term memory loss [3] Complications: Heart disease, loss of ability to care for self and interact, pneumonia [4] Causes: Conditions that impair blood vessels in the brain and therefore interfere with oxygen delivery to the brain [3] Risk ...
Subcortical dementias includes those diseases which predominantly affects the basal ganglia along with features of cognitive decline. Diseases such as progressive supranuclear palsy , Huntington's chorea and Parkinson's disease are different in many features from the other cortical dementias like Alzheimer's disease .
Canavan's disease is initially recognized by the appearance of symptoms, yet further examinations are needed for definitive diagnosis. Neuroimaging techniques such as Computed Tomography (CT) scan or Magnetic Resonance imaging (MRI) are typically used to detect the presence of degenerative subcortical white matter. [26]
The presence of frontal and temporal subcortical cysts is the main factor when diagnosing a patient with this disease. [11] In the late stages of the disease, patients have been noted to develop impaired coordination, overresponsive reflexes, and even seizures. MRI testing is used to study and diagnose patients with this disease.
Others classify them as hippocampal, cortical, and WM lesions, [23] and finally, others give seven areas: intracortical, mixed white matter-gray matter, juxtacortical, deep gray matter, periventricular white matter, deep white matter, and infratentorial lesions. [24] The distribution of the lesions could be linked to the clinical evolution [25]