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Sucralfate is a locally acting substance that in an acidic environment (pH < 4) reacts with hydrochloric acid in the stomach to form a cross-linking, viscous, paste-like material capable of acting as an acid buffer for as long as 6 to 8 hours after a single dose. [29]
Gastritis is the inflammation of the lining of the stomach. [1] It may occur as a short episode or may be of a long duration . [ 1 ] There may be no symptoms but, when symptoms are present, the most common is upper abdominal pain (see dyspepsia ). [ 1 ]
Antacids are also added for further recovery support. Common support drugs of antacids are either H 2 receptor antagonists, and/or a proton pump inhibitor. [7] Sucralfate was used as an option. Parenteral nutrition greatly increased chance of recovery. An esophagectomy can be issued if the disorder is severe enough. [7]
Helicobacter pylori eradication protocols is a standard name for all treatment protocols for peptic ulcers and gastritis in the presence of Helicobacter pylori infection. The primary goal of the treatment is not only temporary relief of symptoms but also total elimination of H. pylori infection.
The H 2 receptor antagonists are a class of drugs used to block the action of histamine on parietal cells in the stomach, decreasing the production of acid by these cells. H 2 antagonists are used in the treatment of dyspepsia, although they have been surpassed in popularity by the more effective [1] proton pump inhibitors.
Sucralfate has similar effectiveness to H 2 receptor blockers; however, sucralfate needs to be taken multiple times a day, thus limiting its use. [9] Baclofen , an agonist of the GABA B receptor, while effective, has similar issues of needing frequent dosing in addition to greater adverse effects compared to other medications.
Chronic radiation proctitis is usually treated first-line with sucralfate enemas. These are non-invasive and are effective in diffuse, distal disease. Other treatments may include mesalamine suppositories, vitamin E, hyperbaric oxygen, or short chain fatty acid enemas; however these treatments are only supported by observational or anecdotal ...
The GI cocktail is a mixture of a viscous anesthetic, an antacid, and an anticholinergic. [1] [2] Common viscous anesthetics use are viscous lidocaine or xylocaine.Common antacids used are magnesium hydroxide, aluminum hydroxide, or simethicone (more commonly known as Mylanta or Maalox). [3]