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IL-7 receptor and signaling, common γ chain (blue) and IL-7 receptor-α (green) IL-7 binds to the IL-7 receptor, a heterodimer consisting of Interleukin-7 receptor alpha and common gamma chain receptor. [18] Binding results in a cascade of signals important for T-cell development within the thymus and survival within the periphery.
The interleukin-7 receptor is a protein found on the surface of cells. It is made up of two different smaller protein chains - i.e. it is a heterodimer , and consists of two subunits, interleukin-7 receptor-α ( CD127 ) and common-γ chain receptor ( CD132 ).
Signalling from these receptors normally promotes growth and differentiation of T-cells, B cells, natural killer cells, glial cells, and cells of the monocyte lineage, depending on the cell type and receptor activated. [11] The most important receptors for X-SCID are those for Interleukin 2, Interleukin 4, Interleukin 7, and Interleukin 15.
Early studies had indicated that Interleukin 9 and 7 seem to be evolutionary related [31] and Pfam, InterPro and PROSITE entries exist for interleukin 7/interleukin 9 family. However, a recent study [ 32 ] has shown that IL-9 is, in fact, much closer to both IL-2 and IL-15, than to IL-7.
Omenn syndrome is an autosomal recessive severe combined immunodeficiency. [1] It is associated with hypomorphic missense mutations in immunologically relevant genes of T-cells (and B-cells) such as recombination activating genes (RAG1 and RAG2), Interleukin-7 receptor-α (IL7Rα), DCLRE1C-Artemis, RMRP-CHH, DNA-Ligase IV, common gamma chain, WHN-FOXN1, ZAP-70 and complete DiGeorge syndrome.
Interleukin-7 receptor subunit alpha (IL7R-α) also known as CD127 (Cluster of Differentiation 127) is a protein that in humans is encoded by the IL7R gene. [5] [6] IL7R-α is a type I cytokine receptor and is a subunit of the functional interleukin-7 receptor and thymic stromal lymphopoietin receptors.
Interleukin 8 receptor, beta; Interleukin receptor; Interleukin-1 receptor; Interleukin-1 receptor family; Interleukin-1 receptor-associated kinase; Interleukin-10 receptor; Interleukin-11 receptor; Interleukin-12 receptor; Interleukin-13 receptor; Interleukin-15 receptor; Interleukin-17 receptor; Interleukin-18 receptor; Interleukin-20 ...
It is a recombinant humanized monoclonal antibody of the immunoglobulin IgG1 subclass against the interleukin-6 receptor (IL-6R). [18] Interleukin 6 (IL-6) is a cytokine that plays an important role in immune response and is implicated in the pathogenesis of many diseases, such as autoimmune diseases, multiple myeloma and prostate cancer.