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Bone density loss can be treated with medication and exercise. It affects more than 50 million people in the United States, and it’s more common in people over 50, according to the Cleveland ...
Levothyroxine, a drug used to treat hypothyroidism, can lead to reduced bone mass and density in older adults with normal thyroid levels, a small cohort study has shown.
Bisphosphonates are a class of drugs that prevent the loss of bone density, used to treat osteoporosis and similar diseases. They are the most commonly prescribed drugs used to treat osteoporosis. [1] They are called bisphosphonates because they have two phosphonate (PO(OH) 2) groups. They are thus also called diphosphonates (bis-or di ...
The drug was then successfully repurposed as a treatment for breast cancer where it was found to act as a full antagonist in breast tissue. [14] Somewhat unexpectedly, it was also discovered that tamoxifen preserves bone density [15] by acting as an agonist in bone resorbing osteoclasts. [16]
The absorbed drug rapidly partitions, with approximately 50% binding to the exposed bone surface; the remainder is excreted unchanged by the kidneys. Unlike with most drugs, the strong negative charge on the two phosphonate moieties limits oral bioavailability, and, in turn, the exposure to tissues other than bone is very low.
This drop in DHEA correlates with age-related changes such as depression, memory problems, ED, decreased libido and bone density loss. Synthetic DHEA is available as an oral supplement or as a cream.