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DNase I contains four ion-binding pockets, and requires Ca 2+ and Mg 2+ for hydrolyzing double-stranded DNA. [5] Two of the sites strongly bind Ca 2+ while the other two coordinate Mg 2+ . Little has been published on the number and location of the Mg 2+ binding sites, although it has been proposed that Mg 2+ is located near the catalytic ...
Deoxyribonuclease II (EC 3.1.22.1, DNase II, pancreatic DNase II, deoxyribonucleate 3'-nucleotidohydrolase, pancreatic DNase II, acid deoxyribonuclease, acid DNase) is an endonuclease that hydrolyzes phosphodiester linkages of deoxyribonucleotide in native and denatured DNA, yielding products with 3'-phosphates and 5'-hydroxyl ends, which occurs as a result of single-strand cleaving mechanism. [1]
56629 Ensembl ENSG00000137976 ENSMUSG00000028185 UniProt Q8WZ79 Q66K39 Q9QY48 RefSeq (mRNA) NM_021233 NM_058248 NM_019957 RefSeq (protein) NP_067056 NP_490649 NP_067056.2 NP_064341 Location (UCSC) Chr 1: 84.4 – 84.42 Mb Chr 3: 146.29 – 146.32 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Deoxyribonuclease 2 beta is a protein that in humans is encoded by the DNASE2B gene ...
Deoxyribonuclease I (usually called DNase I), is an endonuclease of the DNase family coded by the human gene DNASE1. [5] DNase I is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides.
Other notable deoxyribozyme ribonucleases are those that are highly selective for a certain cofactor. Among this group are the metal selective deoxyribozymes such as Pb 2+-specific 17E, [17] UO 2 2+-specific 39E, [18] and Na +-specific A43. [19] First crystal structure of a DNAzyme was reported in 2016.
13423 Ensembl ENSG00000105612 ENSMUSG00000003812 UniProt O00115 P56542 RefSeq (mRNA) NM_001375 NM_010062 NM_001368295 NM_001368296 RefSeq (protein) NP_001366 NP_001366.1 NP_034192 NP_001355224 NP_001355225 Location (UCSC) Chr 19: 12.88 – 12.88 Mb n/a PubMed search Wikidata View/Edit Human View/Edit Mouse Deoxyribonuclease II, lysosomal is a protein that in humans is encoded by the DNASE2 ...
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Pages in category "Deoxyribonucleases" The following 4 pages are in this category, out of 4 total. This list may not reflect recent changes. C. Cas9; E ...