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Acute flaccid myelitis (AFM) is a serious condition of the spinal cord. [3] [5] Symptoms include rapid onset of arm or leg weakness and decreased reflexes. [3]Difficulty moving the eyes, speaking, or swallowing may also occur. [3]
High-dose intravenous methyl-prednisolone for 3–5 days is considered as a standard of care for patients suspected to have acute myelitis, unless there are compelling reasons otherwise. The decision to offer continued steroids or add a new treatment is often based on the clinical course and MRI appearance at the end of five days of steroids. [12]
IgG4-related disease (IgG4-RD), formerly known as IgG4-related systemic disease, is a chronic inflammatory condition characterized by tissue infiltration with lymphocytes and IgG4-secreting plasma cells, various degrees of fibrosis (scarring) and a usually prompt response to oral steroids.
Early initiation of treatment with steroids has been shown to improve vision-related outcomes after acute attacks. [1] [59] However, there is no high-level evidence for steroids affecting long-term outcomes; this treatment strategy was borrowed from that for similar diseases (idiopathic optic neuritis and multiple sclerosis). [59] [58]
Following is a list of reference ranges for cerebrospinal fluid: Ions and metals. Reference ranges for ions and metals in CSF [1] Substance Lower limit Upper limit
Patients with the syndrome had hearing and vision loss and were found to have higher concentrations of lymphocytes and proteins in their cerebrospinal fluid. Treatment with immunosuppressive drugs like prednisone followed by Azathioprine were found to have significant effects and patients gradually regained lost function, in some cases after ...
MOG-IgG is detected by means of so-called cell-based assays (CBA). CBA using live cells transfected with full-length human MOG and employing Fc-specific detection antibodies are the gold standard for anti-MOG antibody testing. [1] Serum is the specimen of choice; cerebrospinal fluid (CSF) analysis is less sensitive compared to serum testing. [1 ...
The most common forms are lumbar spinal stenosis, at the level of the lower back, and cervical spinal stenosis, which are at the level of the neck. [12] Thoracic spinal stenosis, at the level of the mid-back, is much less common. [13] In lumbar stenosis, the spinal nerve roots in the lower back are compressed which can lead to symptoms of ...