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Chromosome 3 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. People normally have two copies of this chromosome. Chromosome 3 spans more than 198 million base pairs (the building material of DNA ) and represents about 6.5 percent of the total DNA in cells .
The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. [8]
In genetics, a locus (pl.: loci) is a specific, fixed position on a chromosome where a particular gene or genetic marker is located. [1] Each chromosome carries many genes, with each gene occupying a different position or locus; in humans, the total number of protein-coding genes in a complete haploid set of 23 chromosomes is estimated at ...
The largest regions on each chromosome are the short arm p and the long arm q, separated by a narrow region near the center called the centromere. [1] Other specific regions have also been defined, some of which are similarly found on every chromosome, while others are only present in certain chromosomes. Named regions include: Arms (p and q ...
20347 Ensembl ENSG00000012171 ENSMUSG00000057969 UniProt Q13214 Q62177 RefSeq (mRNA) NM_001005914 NM_001290060 NM_001290061 NM_001290062 NM_001290063 NM_004636 NM_001042779 NM_001291537 NM_001291538 NM_001291539 NM_009153 RefSeq (protein) NP_001005914 NP_001276989 NP_001276990 NP_001276991 NP_001276992 NP_004627 n/a Location (UCSC) Chr 3: 50.27 – 50.28 Mb Chr 9: 107.47 – 107.49 Mb PubMed ...
Cereblon is a protein that in humans is encoded by the CRBN gene. [5] The gene that encodes the cereblon protein is found on the human chromosome 3, on the short arm at position p26.3 from base pair 3,190,676 to base pair 3,221,394. CRBN orthologs are highly conserved from plants to humans. [5]
The RTP3 gene has been found to be downregulated in liver carcinomas. [12] In cell lines that do not contain p53, a tumor suppressor protein, RTP3 has found to be more highly expressed than in cell lines that do contain the protein. [13]
For example, human chromosome 2, which is believed to be the result of a Robertsonian translocation at some point in the evolution between the great apes and Homo, has a second, vestigial, centromere near the middle of its long arm.