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Chromosome 3 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. People normally have two copies of this chromosome. Chromosome 3 spans more than 198 million base pairs (the building material of DNA ) and represents about 6.5 percent of the total DNA in cells .
Cereblon is a protein that in humans is encoded by the CRBN gene. [5] The gene that encodes the cereblon protein is found on the human chromosome 3, on the short arm at position p26.3 from base pair 3,190,676 to base pair 3,221,394. CRBN orthologs are highly conserved from plants to humans. [5]
•List of human protein-coding genes page 2 covers genes EPHA1–MTMR3 •List of human protein-coding genes page 3 covers genes MTMR4–SLC17A7 •List of human protein-coding genes page 4 covers genes SLC17A8–ZZZ3 NB: Each list page contains 5000 human protein-coding genes, sorted alphanumerically by the HGNC-approved gene symbol.
In genetics, a locus (pl.: loci) is a specific, fixed position on a chromosome where a particular gene or genetic marker is located. [1] Each chromosome carries many genes, with each gene occupying a different position or locus; in humans, the total number of protein-coding genes in a complete haploid set of 23 chromosomes is estimated at ...
The largest regions on each chromosome are the short arm p and the long arm q, separated by a narrow region near the center called the centromere. [1] Other specific regions have also been defined, some of which are similarly found on every chromosome, while others are only present in certain chromosomes. Named regions include: Arms (p and q ...
For example, human chromosome 2, which is believed to be the result of a Robertsonian translocation at some point in the evolution between the great apes and Homo, has a second, vestigial, centromere near the middle of its long arm.
Active genes, which are generally found in the euchromatic region of the chromosome, tend to be located towards the chromosome's territory boundary. [ 6 ] Antibodies to certain types of chromatin organization, in particular, nucleosomes , have been associated with a number of autoimmune diseases , such as systemic lupus erythematosus . [ 7 ]
The RTP3 gene has been found to be downregulated in liver carcinomas. [12] In cell lines that do not contain p53, a tumor suppressor protein, RTP3 has found to be more highly expressed than in cell lines that do contain the protein. [13]