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Cimetidine was the prototypical histamine H 2 receptor antagonist from which later drugs were developed. Cimetidine was the culmination of a project at Smith, Kline & French (SK&F; now GlaxoSmithKline) by James W. Black, C. Robin Ganellin, and others to develop a histamine receptor antagonist that would suppress stomach acid secretion.
They are the most potent inhibitors of acid secretion available. The group followed and has largely superseded another group of pharmaceuticals with similar effects, but a different mode of action, called H 2-receptor antagonists. These drugs are among the most widely sold drugs in the world, and are generally considered effective. [3]
Hydroxyzine works by blocking the effects of histamine. [9] It is a first-generation antihistamine in the piperazine family of chemicals. [8] [4] Common side effects include sleepiness, headache, and dry mouth. [8] [9] Serious side effects may include QT prolongation. [9] It is unclear if use during pregnancy or breastfeeding is safe. [8]
The U.S. Preventive Services Task Force released a draft recommendation advising against using vitamin D to prevent falls and fractures in people over 60. Pharmacist Katy Dubinsky weighs in.
As of March 2017, benefits outweighed risks when PPIs are used appropriately, but when used inappropriately, modest risks become important. [ 34 ] [ 36 ] They recommend that PPIs should be used at the lowest effective dose in people with a proven indication, but discourage dose escalation and continued chronic therapy in people unresponsive to ...
beta-blockers, calcium channel blockers, and renin-angiotensin system-acting agents, which all help lower blood pressure. They also examined the combination use of these medications.
The "healthspan-lifespan gap" was largest in the U.S., as Americans live in poor health for an average of 12.4 years, compared to 10.9 years in 2000.
Common side effects include headache, abdominal pain, diarrhea or constipation, and dizziness. [4] Serious side effects may include pneumonia and seizures. [4] [5] Use in pregnancy appears safe but has not been well studied, while use during breastfeeding is not recommended. [1] Famotidine was patented in 1979 and came into medical use in 1985. [6]