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Natural selection for genomic imprinting requires genetic variation in a population. A hypothesis for the origin of this genetic variation states that the host-defense system responsible for silencing foreign DNA elements, such as genes of viral origin, mistakenly silenced genes whose silencing turned out to be beneficial for the organism. [63]
Genomic imprinting represents yet another example of non-Mendelian inheritance. Just as in conventional inheritance, genes for a given trait are passed down to progeny from both parents. However, these genes are epigenetically marked before transmission, altering their levels of expression. These imprints are created before gamete formation and ...
Genomic imprinting is an epigenetic process by which certain genes are expressed in a parent-of-origin-specific manner. The imprinted brain theory is a variant of the kinship theory of genomic imprinting, also known as the conflict theory of genomic imprinting.
10984 n/a Ensembl ENSG00000269821 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 11: 2.61 – 2.7 Mb n/a PubMed search n/a Wikidata View/Edit Human KCNQ1 overlapping transcript 1, also known as KCNQ1OT1, is a long non-coding RNA gene found in the KCNQ1 locus. This locus consists of 8–10 protein-coding genes, specifically expressed from the maternal ...
283120 n/a Ensembl ENSG00000130600 ENSG00000288237 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 11: 2 – 2 Mb n/a PubMed search n/a Wikidata View/Edit Human H19 is a gene for a long noncoding RNA, found in humans and elsewhere. H19 has a role in the negative regulation (or limiting) of body weight and cell proliferation. This gene also has a role in ...
Constitutive monoallelic expression occurs from the same specific allele throughout the whole organism or tissue, as a result of genomic imprinting. [5] RME is a broader class of monoallelic expression, which is defined by random allelic choice in somatic cells, so that different cells of the multi-cellular organism express different alleles.
Ferguson-Smith is an authority on genomic imprinting and the epigenetic control of genome function in health and disease, and is recognised for her work on parental-origin effects and epigenetic mechanisms. [2]
The kinship theory of genomic imprinting. Annual Review of Ecology and Systematics, 31, 9-32. Wilkins, J. F. & Haig, D. (2003) .What good is genomic imprinting: the function of parent-specific gene expression. Nature Reviews Genetics, 4, 359-368. Haig, D. (2004). Genomic imprinting and kinship: how good is the evidence?