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The Wolff–Kishner reduction is a reaction used in organic chemistry to convert carbonyl functionalities into methylene groups. [1] [2] In the context of complex molecule synthesis, it is most frequently employed to remove a carbonyl group after it has served its synthetic purpose of activating an intermediate in a preceding step.
The reaction is occasionally called the Wolff-Schröter rearrangement. [2] The Wolff rearrangement was not commonly used until 20 years after it was discovered, as facile diazo ketone synthesis was unknown until the 1930s. [2] The reaction has proven useful in synthetic organic chemistry and many reviews have been published. [1] [2] Wolff's ...
Some reactions for this transformation include the Clemmensen reduction (in strongly acidic conditions) and the Wolff–Kishner reduction (in strongly basic conditions), as well as the various modifications of Wolff-Kishner reaction.
The Knorr pyrrole synthesis is a widely used chemical reaction that synthesizes substituted pyrroles (3). [1] [2] [3] The method involves the reaction of an α-amino-ketone (1) and a compound containing an electron-withdrawing group (e.g. an ester as shown) α to a carbonyl group (2). [4] The Knorr pyrrole synthesis
Ludwig Wolff (27 September 1857 – 24 February 1919), born in Neustadt in Palatinate, was a German chemist. [1] He studied chemistry at the University of Strasbourg, where he received his Ph.D. from Rudolph Fittig in 1882. He became Professor of analytical chemistry at the University of Jena in 1891 and held this position till his death in 1919.
This reaction is related to several classic named reactions: The acylated reaction product can be converted into the alkylated product via a Clemmensen or a Wolff-Kishner reduction. [17] The Gattermann–Koch reaction can be used to synthesize benzaldehyde from benzene. [18] The Gatterman reaction describes arene reactions with hydrocyanic acid ...
Wolf. Boy Names Go Out of This World. If it's not fantasy that's ruling over boys' names, it's sci-fi, with The Bump also reporting an uptick in interest in space-themed names inspired by ...
For the second generation reaction starting with the diazoketone, the reaction is performed by irradiation of a 0.7 M solution of the ketone with 1.0-1.2 equivalents of acetylene. A low-pressure mercury-vapor lamp at 254 nm in a photochemical reactor is used for 5–8 hours until all the diazoketone has been consumed as determined by TLC analysis.