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Tumors that occur in the posterior fossa have also been shown to have a less favorable prognosis. [46] Expression of TERT in pediatric intracranial ependymomas is correlated with telomerase activity and tumor progression and negatively correlated with survival. [47]
Medulloblastoma is a common type of primary brain cancer in children. It originates in the part of the brain that is towards the back and the bottom, on the floor of the skull, in the cerebellum, or posterior fossa. [3] The brain is divided into two main parts, the larger cerebrum on top and the smaller cerebellum below towards the back.
Since many of the tumors occur in the posterior fossa, they present like other posterior fossa tumors, often with headache, vomiting, lethargy, and ataxia (unsteady gait). A case of a seven-month-old child with a primarily spinal tumor that presented with progressive paraplegia and abnormal feeling in the legs was reported. [9]
Ependymomas are composed of cells with regular, round to oval nuclei. There is a variably dense fibrillary background. Tumor cells may form gland-like round or elongated structures that resemble the embryologic ependymal canal, with long, delicate processes extending into the lumen; more frequently present are perivascular pseudorosettes in which tumor cells are arranged around vessels with an ...
A posterior fossa tumor leading to mass effect and midline shift. There are no specific signs or symptoms for brain cancer, but the presence of a combination of symptoms and the lack of alternative causes may indicate a brain tumor. [41] A medical history aids in the diagnosis. Clinical and laboratory investigations will serve to exclude ...
Leptomeningeal cancer is a rare complication of cancer in which the disease spreads from the original tumor site to the meninges surrounding the brain and spinal cord. [1] This leads to an inflammatory response, hence the alternative names neoplastic meningitis (NM), malignant meningitis , or carcinomatous meningitis .
The translabyrinthine approach is a surgical approach to treating serious disorders of the cerebellopontine angle, (CPA), which is the most common location of posterior fossa tumors. especially acoustic neuroma. [1]
Herniation can be caused by a number of factors that cause a mass effect and increase intracranial pressure (ICP): these include traumatic brain injury, intracranial hemorrhage, or brain tumor. [1] Herniation can also occur in the absence of high ICP when mass lesions such as hematomas occur at the borders of brain compartments. In such cases ...
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