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Meta-analysis of clinical trials has shown this combined therapy to be more effective than either of its ingredients by themselves. [6]The use of adapalene/benzoyl peroxide in combination with oral antibiotics (lymecycline) has been studied; [7] the combination was well tolerated and showed an improved success rate compared to those receiving only antibiotics (47.6% vs. 33.7%, P = 0.002).
It contains clindamycin, as the phosphate, a lincosamide antibacterial; adapalene, a synthetic retinoid; and benzoyl peroxide, an oxidizing agent. [2] It is applied to the skin . [ 2 ]
Adapalene, sold under the brand name Differin among others, is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne, and is also used off-label to treat keratosis pilaris as well as other skin conditions. [6] Studies have found adapalene is as effective as other retinoids, while causing less irritation. [7]
Benzoyl peroxide is a common acne-fighting ingredient found in a variety of skin care products. Shop cleansers, treatments and more from brands like Cerave and La Roche Posay.
Tazarotene is most commonly used topically to treat acne vulgaris and psoriasis. [4] Like other topical retinoids, such as tretinoin and adapalene, tazarotene can be combined with benzoyl peroxide or an oral antibiotic, such as clindamycin or dapsone, for the treatment of acne. [8]
The drug can penetrate deeply into the skin [2] and be directly delivered to the target site, as the topical application allows it to avoid hepatic first pass metabolism. [ 1 ] [ 2 ] [ 8 ] [ 6 ] Difficulties in gastrointestinal absorption caused by pH, enzymatic activity and drug-food interactions can be minimized, while at the same time ...
There is a real difference in the eye shadow color and time of wear when it is used over the primer on bare skin. [2] The effect of eye shadow primers is not limited to eye shadows. They also work for eye liners and eye shadow bases. Under-eye primer is designed to be applied before concealer to reduce the appearance of fine lines and wrinkles.
A primer dimer (PD) is a potential by-product in the polymerase chain reaction (PCR), a common biotechnological method. As its name implies, a PD consists of two primer molecules that have attached to each other because of strings of complementary bases in the primers.