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para-Methoxyamphetamine (PMA), also known as 4-methoxyamphetamine (4-MA), is a designer drug of the amphetamine class with serotonergic effects. [2] [3] [4] Unlike other similar drugs of this family, PMA does not produce stimulant, euphoriant, or entactogen effects, [5] and behaves more like an antidepressant in comparison, [6] though it does have some psychedelic properties.
para-Methoxymethamphetamine (PMMA), also known as 4-methoxy-N-methylamphetamine (4-MMA), is a serotonergic drug of the amphetamine family related to para-methoxyamphetamine (PMA). It is the 4- methoxy analogue of methamphetamine .
para-Methoxy ethyl amphetamine (PMEA), is a stimulant drug related to PMA. PMEA reputedly produces similar effects to PMA, but is considerably less potent [1] and seems to have slightly less tendency to produce severe hyperthermia, at least at low doses. At higher doses however the side effects and danger of death approach those of PMA itself ...
4-Methylthioamphetamine (4-MTA), also known as para-methylthioamphetamine (MTA), is a designer drug of the substituted amphetamine class developed in the 1990s by a team led by David E. Nichols, an American pharmacologist and medical chemist, at Purdue University. It acts as a non-neurotoxic highly selective serotonin releasing agent (SSRA) in ...
para-Methoxyamphetamine (PMA or "Dr. Death", a drug that causes so much overheating that it can kill within 40 minutes) is sometimes sold as ecstasy. [ citation needed ] There is one published case [ 47 ] of an ecstasy tablet being adulterated with 8 mg of strychnine , a toxic alkaloid which was used in very low doses (less than 1 mg) as a ...
TMA is also a very low-potency serotonin releasing agent (SRA), with an EC 50 value of 16,000 nM. [7] In contrast, it is inactive as a releasing agent and reuptake inhibitor of dopamine and norepinephrine (EC 50 > 100,000 nM). [7] Despite its apparent SRA activity in vitro, TMA did not increase brain serotonin or dopamine levels in rodents in ...
In vitro, 4-methylamphetamine acts as a potent and well-balanced serotonin, norepinephrine, and dopamine releasing agent (SNDRA) with EC 50 Tooltip half-maximal effective concentration values of 53.4 nM, 22.2 nM, and 44.1 nM at the serotonin, norepinephrine, and dopamine transporters, respectively.
3-Methoxyamphetamine (3-MA), also known as meta-methoxyamphetamine (MMA), is a monoamine releasing agent (MRA) of the amphetamine family. [ 2 ] [ 3 ] [ 4 ] It is a positional isomer of para -methoxyamphetamine (PMA; 4-methoxyamphetamine).