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  2. Bortezomib - Wikipedia

    en.wikipedia.org/wiki/Bortezomib

    [22] [23] In 2008, bortezomib was approved in the United States for initial treatment of people with multiple myeloma. [24] Bortezomib was previously approved in 2005, for the treatment of people with multiple myeloma who had received at least one prior therapy and in 2003, for the treatment of more refractory multiple myeloma. [24]

  3. Multiple myeloma - Wikipedia

    en.wikipedia.org/wiki/Multiple_myeloma

    MGUS is a relatively stable condition afflicting 3% of people aged 50 and 5% of people aged 70; it progresses to multiple myeloma at a rate of 0.5–1% cases per year; smoldering multiple myeloma does so at a rate of 10% per year for the first 5 years, but then falls off sharply to 3% per year for the next 5 years and thereafter to 1% per year.

  4. Monoclonal immunoglobulin deposition disease - Wikipedia

    en.wikipedia.org/wiki/Monoclonal_immunoglobulin...

    LCDD is associated with multiple myeloma in 39-59% of cases, with monoclonal gammopathy of renal significance in 39% of cases and may also be associated with lymphoplasmacytic lymphoma. [2] The median 5-year overall survival of LCDD patients is 70%.

  5. GSK's blood cancer drug meets primary goal in late-stage trial

    www.aol.com/news/gsk-says-blood-cancer-drug...

    Barclays analysts said expectations had been very low for Blenrep in remaining multiple myeloma trials but that the results from the study dubbed "DREAMM-7" were a slight positive.

  6. Bruce Springsteen's wife Patti Scialfa reveals blood cancer ...

    www.aol.com/bruce-springsteens-wife-patti...

    The five-year survival rate for multiple myeloma patients ranges from 40% to 82%, per the Cleveland Clinic, which notes that it affects about seven out of 100,000 people a year and that "some ...

  7. Proteasome inhibitor - Wikipedia

    en.wikipedia.org/wiki/Proteasome_inhibitor

    Bortezomib (Velcade) was approved in 2003. This was the first proteasome inhibitor approved for use in the U.S. Its boron atom binds the catalytic site of the 26S proteasome. [20] Carfilzomib (Kyprolis) was approved by the FDA for relapsed and refractory multiple myeloma in 2012 . [21]

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