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The pharmacokinetics of epirubicin appear to be linear for doses in the range of 40 – 150 mg/m2. [9] [10] [11] The volume of distribution of epirubicin is found to be high and variable (1 000- 1 500), but similar to those reported for doxorubicin. [7] [8] [10] This indicates extensive distribution into the tissue. The total plasma clearance ...
Tumor stroma and extracellular matrix in hypoxia. Tumor hypoxia is the situation where tumor cells have been deprived of oxygen.As a tumor grows, it rapidly outgrows its blood supply, leaving portions of the tumor with regions where the oxygen concentration is significantly lower than in healthy tissues.
[16] [17] Area under the plasma concentration-time curve had a mean value of 2.8 mg.h/L. [16] The Cmax of docetaxel was found to be 4.15 ± 1.35 mg/L. [36] Increased dose resulted in a linear increase of the area under the concentration-time curve and so it is concluded that dose is directly proportional to plasma concentration. [16]
3D model of the flu virion. (M2 labeled in white.) The Matrix-2 (M2) protein is a proton-selective viroporin, integral in the viral envelope of the influenza A virus. The channel itself is a homotetramer (consists of four identical M2 units), where the units are helices stabilized by two disulfide bonds, and is activated by low pH.
[19] [20] [21] Across all administered dose levels (25 mg/m 2 for the i.m. route of administration and 37.5 mg/m 2 for the i.v. route), JZP-458 exhibited favorable tolerability without any unexpected adverse events (AEs), serious AEs, or AEs of grade 3 or higher. Among the treatment-emergent AEs reported, nausea was the most frequently observed ...
Bromazepam, sold under many brand names, is a benzodiazepine.It is mainly an anti-anxiety agent with similar side effects to diazepam.In addition to being used to treat anxiety or panic states, bromazepam may be used as a premedicant prior to minor surgery.
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