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Giardiasis is a parasitic disease caused by Giardia duodenalis (also known as G. lamblia and G. intestinalis). [3] Infected individuals who experience symptoms (about 10% have no symptoms) may have diarrhea, abdominal pain, and weight loss. [1] Less common symptoms include vomiting and blood in the stool. [1]
Trophozoites adhere to host epithelial cells via a specialized disk-shaped organelle called the ventral disk. [14] Cysts are oval-shaped cells slightly smaller than trophozoites. [15] They lack flagella, and are covered by a smooth, clear cyst wall. [15] Each cyst contains four nuclei and fragments of the ventral disc. [15]
Giardia (/ dʒ iː ˈ ɑːr d i ə / or / ˈ dʒ ɑːr d i ə /) is a genus of anaerobic flagellated protozoan parasites of the phylum Metamonada that colonise and reproduce in the small intestines of several vertebrates, causing the disease giardiasis. Their life cycle alternates between a swimming trophozoite and an infective, resistant cyst.
Giardiasis: Giardia lamblia: lumen of the small intestine: stool worldwide? ingestion of water containing deer or beaver feces Isosporiasis: Isospora belli: epithelial cells of small intestines: stool worldwide – less common than Toxoplasma or Cryptosporidium: fecal oral route – ingestion of sporulated oocyst Leishmaniasis: Leishmania spp.
Gastrointestinal conditions include inflammation of the small and/or large intestine, diarrhea/dysentery, abdominal pains, and nausea/vomiting. These symptoms negatively impact nutritional status, including decreased absorption of micronutrients, loss of appetite, weight loss, and intestinal blood loss that can often result in anemia.
The gut-associated lymphoid tissue lies throughout the intestine, covering an area of approximately 260–300 m 2. [5] In order to increase the surface area for absorption, the intestinal mucosa is made up of finger-like projections (), covered by a monolayer of epithelial cells, which separates the GALT from the lumen intestine and its contents.
[1] [10] Other symptoms may include fever, abdominal pain, and a feeling of incomplete defecation. [2] [6] [11] Complications may include dehydration. [3] The cause of dysentery is usually the bacteria from genus Shigella, in which case it is known as shigellosis, or the amoeba Entamoeba histolytica; then it is called amoebiasis. [1]
These cysts on reaching the terminal ileum region of the gastrointestinal tract give rise to a mass of proliferating cells, the trophozoite form of the parasite, by the process of excystation. [22] Symptoms of this infection include diarrhea with blood and mucus, and can alternate between constipation and remission, abdominal pain, and fever.