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It is a rare blood condition in which the β-pyrrole ring of the hemoglobin molecule has the ability to bind irreversibly to any substance containing a sulfur atom. [1] [2] When hydrogen sulfide (H 2 S) (or sulfide ions) and ferrous ions combine in the heme of hemoglobin, the blood is thus incapable of transporting oxygen to the tissues.
Hydrogen sulfide is also involved in the disease process of type 1 diabetes. The beta cells of the pancreas in type 1 diabetes produce an excess of the gas, leading to the death of these cells and to a reduced production of insulin by those that remain. [5] In 2005, it was shown that mice can be put into a state of suspended animation-like ...
Hydrogen sulfide is a chemical compound with the formula H 2 S.It is a colorless chalcogen-hydride gas, and is poisonous, corrosive, and flammable, with trace amounts in ambient atmosphere having a characteristic foul odor of rotten eggs. [11]
During a stroke, there is an interruption in the blood supply followed by reperfusion which leads to histotoxic hypoxia because of an accumulation of reactive oxygen species (ROS). [4] In the case of inflammatory diseases, histotoxic hypoxia can also be triggered by ROS from mitochondrial damage in the active lesions of chronic multiple sclerosis.
A chemical weapon agent (CWA), or chemical warfare agent, is a chemical substance whose toxic properties are meant to kill, injure or incapacitate human beings.About 70 different chemicals have been used or stockpiled as chemical weapon agents during the 20th century, although the Organisation for the Prohibition of Chemical Weapons (OPCW) has an online database listing 35,942 chemicals which ...
DATS can be metabolized by glutathione in red blood cells to form hydrogen sulfide (H2S). [5] This conversion occurs at a consistent rate over a prolonged period of time, rendering DATS a good source of H2S. [6] H2S is a cardioprotective agent that has antioxidant, anti-inflammatory, and anti-apoptotic effects.
Hydrogen sulfide life might use a mixture of carbon monoxide and carbon dioxide as their carbon source. They might produce and live on sulfur monoxide , which is analogous to oxygen (O 2 ). Hydrogen sulfide, like hydrogen cyanide and ammonia, suffers from the small temperature range where it is liquid, though that, like that of hydrogen cyanide ...
Relative to carbon monoxide and hydrogen sulfide, NO is exceptional due to the fact it is a radical gas. [28] NO is highly reactive (having a lifetime of a few seconds), yet diffuses freely across membranes. These attributes make NO ideal for a transient paracrine (between adjacent cells) and autocrine (within a single cell) signaling molecule.