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Chemokines (from Ancient Greek χῠμείᾱ (khumeíā) 'alchemy' and κῑ́νησῐς (kī́nēsis) 'movement'), or chemotactic cytokines, are a family of small cytokines or signaling proteins secreted by cells that induce directional movement of leukocytes, as well as other cell types, including endothelial and epithelial cells.
C-C chemokine receptor type 2 (CCR2 or CD192 (cluster of differentiation 192) is a protein that in humans is encoded by the CCR2 gene. [5] CCR2 is a CC chemokine receptor . Gene
Chemokine receptors are cytokine receptors found on the surface of certain cells that interact with a type of cytokine called a chemokine. [ 1 ] [ 2 ] There have been 20 distinct chemokine receptors discovered in humans. [ 3 ]
Chemokine receptors, two of which act as binding proteins for HIV (CD4 and CCR5), also belong to this family. [citation needed] Interleukin-17 receptor (IL-17R) family, which shows little homology with any other cytokine receptor family. Structural motifs conserved between members of this family include: an extracellular fibronectin III-like ...
CCL2 is a small cytokine that belongs to the CC chemokine family. CCL2 tightly regulates cellular mechanics [ 5 ] and thereby recruits monocytes , memory T cells , and dendritic cells to the sites of inflammation produced by either tissue injury or infection .
CC chemokine receptors (or beta chemokine receptors) are integral membrane proteins that specifically bind and respond to cytokines of the CC chemokine family. They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM) proteins since they span the cell membrane seven times.
2833 12766 Ensembl ENSG00000186810 ENSMUSG00000050232 UniProt P49682 O88410 RefSeq (mRNA) NM_001142797 NM_001504 NM_009910 RefSeq (protein) NP_001136269 NP_001495 NP_034040 Location (UCSC) Chr X: 71.62 – 71.62 Mb Chr X: 100.78 – 100.78 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Chemokine receptor CXCR3 is a Gα i protein-coupled receptor in the CXC chemokine receptor family ...
The biological effect is carried out through ligation of chemokine receptors CCR1 (ligand CCL3) and CCR5 (ligands CCL3 and CCL4) and the signal is then transferred into the cell, thus these cytokines affect any cell that has these receptors. [8]