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Chronic kidney disease, excretion of magnesium becomes impaired when creatinine clearance falls below 30 ml/min. However, hypermagnesemia is not a prominent feature of chronic kidney disease unless magnesium intake is increased. [citation needed] Magnesium toxicity from emergency pre-eclampsia treatment during labor and delivery. [citation needed]
Magnesium sulfate or magnesium sulphate is a chemical compound, a salt with the formula MgSO 4, consisting of magnesium cations Mg 2+ (20.19% by mass) and sulfate anions SO 2− 4. It is a white crystalline solid , soluble in water but not in ethanol .
Magnesium sulfate is effective in decreasing the risk that pre-eclampsia progresses to eclampsia. [24] Intravenous magnesium sulfate is used to prevent and treat seizures of eclampsia. It reduces the systolic blood pressure but does not alter the diastolic blood pressure, so the blood perfusion to the fetus is not compromised.
Normal magnesium levels are between 0.6 and 1.1 mmol/L (1.46–2.68 mg/dL) with levels less than 0.6 mmol/L (1.46 mg/dL) defining hypomagnesemia. [1] Specific electrocardiogram (ECG) changes may be seen. [1] Treatment is with magnesium either by mouth or intravenously. [2] For those with severe symptoms, intravenous magnesium sulfate may be ...
Magnesium sulfate (Epsom salts) is soluble in water. It is commonly used as a laxative, owing to the poor absorption of the sulfate component. In lower doses, they may be used as an oral magnesium source, however. Intravenous or intramuscular magnesium is generally in the form of magnesium sulfate solution. Intravenous or intramuscular ...
Intravenous magnesium sulfate can reduce calcium ions influx into smooth muscle cells on the airway, causing airway muscle relaxation. [13] It is possible for intravenous magnesium sulfate to cause hypermagnesemia, resulting in muscle weakness. Intravenous magnesium sulfate is contraindicated in patients with renal insufficiency. [14] [15]
It is important to avoid magnesium toxicity, including thoracic muscle paralysis, which could cause respiratory failure and death. Magnesium sulfate results in better outcomes than diazepam, phenytoin or a combination of chlorpromazine, promethazine, and pethidine. [61] [62] [63]
Initial treatment for severe disease is with intravenous calcium chloride and possibly magnesium sulfate. [1] Other treatments may include vitamin D, magnesium, and calcium supplements. [2] If due to hypoparathyroidism, hydrochlorothiazide, phosphate binders, and a low salt diet may also be recommended. [2]