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The Cancer Genome Atlas (TCGA) is a project to catalogue the genomic alterations responsible for cancer using genome sequencing and bioinformatics. [1] [2] The overarching goal was to apply high-throughput genome analysis techniques to improve the ability to diagnose, treat, and prevent cancer through a better understanding of the genetic basis of the disease.
The Atlas is part of the genome project and participates in research on cancer epidemiology. The Atlas is accessed by: 1- researchers in cytogenetics , molecular biology , cell biology ; 2- clinicians, haematologists, cytogeneticists, pathologists, from the university hospitals, indeed, but also from general hospitals where the Atlas is one of ...
The Cancer Genome Atlas →: National Cancer Institute, United States Copy number, Mutation, Methylation, Gene Expression, miRNA expression: Yes Yes Human: No Yes Yes CancerResource →: University Medicine Berlin, Germany Roche Cancer Genome Database (RCGDB) Roche Diagnostics, Penzberg, Germany Network of Cancer Genes →: King's College ...
Pan-cancer Whole-Genome Comparison of Primary and Metastatic Solid Tumours is a comprehensive research study published in Nature exploring genomic disparities between untreated early-stage primary tumors and treated late-stage metastatic tumors. Conducted through a harmonized analysis of 7,108 whole-genome-sequenced tumors across 23 cancer ...
Whole exome sequencing has been the conventional data used by international cancer genome research programs such as The Cancer Genome Atlas (TCGA) and The International Cancer Genome Consortium (ICGC). [15] [16] These studies have accumulated WES data for all types of human tumours and have been an open resource for clinical scientists ...
Cancer Systems Biology is steadily improving our ability to organize information on cancer, in order to fill these gaps. Key developments include: The generation of comprehensive molecular datasets (genome, transcriptome, epigenomics, proteome, metabolome, etc.) The Cancer Genome Atlas data collection [12]
The bulk of Sage's scientific results emerge from cancer and neurosciences, with notable contributions to the Cancer Genome Atlas Pan-Cancer project. [10] Another Sage initiative, The Resilience Project [11] describes itself as a search for individuals who have genetic changes expected to cause severe illness but who remain perfectly healthy.
The Developmental Therapeutics Program (DTP) operates a tiered anti-cancer compound screening program with the goal of identifying novel chemical leads and biological mechanisms. The DTP screen is a three phase screen which includes: an initial screen which first involves a single dose cytotoxicity screen with the 60 cell line assay .