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Drug tolerance or drug insensitivity is a pharmacological concept describing subjects' reduced reaction to a drug following its repeated use. Increasing its dosage may re-amplify the drug's effects; however, this may accelerate tolerance, further reducing the drug's effects.
The lyrical content and tone varies much between the group's many songs, and some records feature complex meanings beyond being just 'anti-drugs' or 'pro-drugs'. For example, 1965's " Day Tripper " focuses lyrically on criticizing a woman who's "taking the easy way out" of her life's troubles and is "a big teaser" while musically being an ...
Drug intolerance or drug sensitivity refers to an inability to tolerate the adverse effects of a medication, generally at therapeutic or subtherapeutic doses. Conversely, a patient is said to be "tolerating" a drug when they can tolerate its adverse effects.
The name golf is not an acronym for "Gentlemen Only, Ladies Forbidden". [268] [269] It may have come from the Dutch word kolf or kolve, meaning "club", [269] or from the Scottish word goulf or gowf meaning "to strike or cuff". [268] Baseball was not invented by Abner Doubleday, nor did it originate in Cooperstown, New York.
An issue with this theory is that most addictive drugs cause an individual to build up a tolerance and the effects of the drug will decrease as an individual's tolerance increases. This requires individuals to use a higher dosage of the substance which in many causes can cause adverse side effects. [34] Dopamine is correlated with increased ...
Drug addiction, which belongs to the class of substance-related disorders, is a chronic and relapsing brain disorder that features drug seeking and drug abuse, despite their harmful effects. [31] This form of addiction changes brain circuitry such that the brain's reward system is compromised, [ 32 ] causing functional consequences for stress ...
Tachyphylaxis (Greek ταχύς, tachys, "rapid", and φύλαξις, phylaxis, "protection") is a medical term describing an acute, sudden decrease in response to a drug after its administration (i.e., a rapid and short-term onset of drug tolerance). [1] It can occur after an initial dose or after a series of small doses.
Cross-tolerance is a phenomenon that occurs when tolerance to the effects of a certain drug produces tolerance to another drug. It often happens between two drugs with similar functions or effects—for example, acting on the same cell receptor or affecting the transmission of certain neurotransmitters .