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Cyclobenzaprine is used to treat such muscle spasms associated with acute, painful musculoskeletal conditions. [12] It decreases pain in the first two weeks, [13] [14] peaking in the first few days, but has no proven benefit after two weeks. [13] [15] Since no benefit is proven beyond that, therapy should not be continued long-term. [12]
Clonidine and other imidazoline compounds have also been shown to reduce muscle spasms by their central nervous system activity. Tizanidine is perhaps the most thoroughly studied clonidine analog, and is an agonist at α 2 -adrenergic receptors , but reduces spasticity at doses that result in significantly less hypotension than clonidine. [ 26 ]
Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It can also be administered for acute pain in general and for tension headache (muscle contraction headache).
Another class of antispasmodics for such treatment includes cyclobenzaprine, carisoprodol, diazepam, orphenadrine, and tizanidine. [7] Meprobamate is another effective antispasmodic which was first introduced for clinical usage in 1955 mainly as an anxiolytic and soon afterward became a blockbuster psychotropic drug.
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Metaxalone exhibits increased bioavailability when taken with food. [3] Specifically, in one study, compared to fasted conditions, the presence of food at the time of drug administration increased C max by 77.5%, AUC 0-t by 23.5%, and AUC 0-∞ by 15.4%. [4]
Phillip Picone's trial was the first to be held after dozens of tickets were issued against volunteers for the group Food Not Bombs.
Amrix, Celphalon's new time-released version of cyclobenzaprine costs over $500 USD per month. The same amount (mg/day) of generic cyclobenzaprine is about $20 USD per month. A script for this new time-released version of cyclobenzaprine cannot be filled generically because the dosing amounts / periods cannot be translated by the pharmacists.