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  2. Hepatotoxicity - Wikipedia

    en.wikipedia.org/wiki/Hepatotoxicity

    Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage. Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval.

  3. Acute liver failure - Wikipedia

    en.wikipedia.org/wiki/Acute_liver_failure

    Patients presenting as acute and hyperacute liver failure are at greater risk of developing cerebral edema and grade IV encephalopathy. The pathogenesis remains unclear, but is likely to be a consequence of several phenomena. There is a buildup of toxic substances like ammonia, mercaptan, serotonin and tryptophan in the brain.

  4. Rumack–Matthew nomogram - Wikipedia

    en.wikipedia.org/wiki/Rumack–Matthew_nomogram

    The Rumack–Matthew nomogram, also known as the acetaminophen nomogram, is an acetaminophen toxicity nomogram. It plots serum concentration of acetaminophen against the time since ingestion, in order to predict possible liver toxicity and allow a clinician to decide whether to proceed with N-Acetylcysteine (NAC) treatment.

  5. Liver disease - Wikipedia

    en.wikipedia.org/wiki/Liver_disease

    Liver diseases, including conditions such as non-alcoholic fatty liver disease (NAFLD), alcohol-related liver disease (ALD), and viral hepatitis, are significant public health concerns worldwide. In the United States, NAFLD is the most common chronic liver condition, affecting approximately 24% of the population, with the prevalence rising due ...

  6. Chronic liver disease - Wikipedia

    en.wikipedia.org/wiki/Chronic_liver_disease

    Some support may be found in the orthodox medical use of two of these in acute liver failure: N-acetyl cysteine (NAC) is the treatment of choice for acetaminophen overdose; [6] both NAC and milk-thistle (Silybum marianum) or its derivative silibinin are used in liver poisoning from certain mushrooms, notably Amanita phalloides, although the use ...

  7. Paracetamol poisoning - Wikipedia

    en.wikipedia.org/wiki/Paracetamol_poisoning

    With early treatment liver failure is rare. [6] Death occurs in about 0.1% of cases. [1] Paracetamol poisoning was first described in the 1960s. [6] Rates of poisoning vary significantly between regions of the world. [8] In the United States more than 100,000 cases occur a year. [1]