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Sir James Whyte Black OM FRS FRSE FRCP (14 June 1924 – 22 March 2010 [2]) was a Scottish physician and pharmacologist. Together with Gertrude B. Elion and George H. Hitchings, he shared the Nobel Prize for Medicine in 1988 for pioneering strategies for rational drug-design, which, in his case, led to the development of propranolol and ...
In 1964, James Black [6] synthesized the first clinically significant beta blockers—propranolol and pronethalol; it revolutionized the medical management of angina pectoris [7] and is considered by many to be one of the most important contributions to clinical medicine and pharmacology of the 20th century. [8]
Pronethalol was only marketed for use in life-threatening situations. Dr. James Black went on to create another β-blocker, called propranolol; a non-selective β-blocker. Clinical trials started in the summer of 1964 and a year later, propranolol was launched under the trade name Inderal, only two and a half years after it had first been ...
SMILES. CC (C)NCC (C1=CC2=CC=CC=C2C=C1)O. Pronethalol (also known as nethalide or compound 38,174; trade name Alderlin) was an early non-selective beta blocker clinical candidate. It was the first beta blocker to be developed by James Black and associates at Imperial Chemical Industries, and the first to enter clinical use, in November 1963.
Scottish scientist James W. Black developed propranolol in the 1960s. [74] It was the first beta-blocker effectively used in the treatment of coronary artery disease and hypertension. [75] Newer, more cardio-selective beta blockers (such as bisoprolol, nebivolol, carvedilol, or metoprolol) are used preferentially in the treatment of ...
Jointly with Sir James Black (Nobel Prize winner in 1988) he discovered the beta-blocking drug, propranolol, in 1962. [3] In 1964 he classified beta adrenergic receptors in beta one and beta two and as a result developed the first drug ( practoLol ) to selectively block beta one receptors. [ 4 ]
The first-in-class β-blocker pronethalol was developed by James Black at ICI Pharmaceuticals. It was followed by propranolol, sotalol, practolol, metoprolol, labetalol, acebutolol and bisoprolol. Successive differences between β-blockers have had a combined cumulative effect and are seen as "innovative". [1]
The first beta blocker, propranolol, was introduced in the early 1960s by the winner of The Nobel Prize in Physiology or Medicine 1988- Sir James W. Black. [23] The drug was originally developed in order to induce a calm effect on the heart by blocking the beta receptor for adrenaline, treating a range of cardiovascular disorders. [23]