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Paracetamol poisoning, also known as acetaminophen poisoning, is caused by excessive use of the medication paracetamol (acetaminophen). [ 2 ] Most people have few or non-specific symptoms in the first 24 hours following overdose. These symptoms include feeling tired, abdominal pain, or nausea. This is typically followed by absence of symptoms ...
Paracetamol or acetaminophen (trade name Panadol and Tylenol) is extremely toxic to cats, and should not be given to them under any circumstances. Cats lack the necessary glucuronyl transferase enzymes to safely break paracetamol down and minute portions of a normal tablet for humans may prove fatal. [ 24 ]
[6] Paracetamol's bioavailability is dose-dependent: it increases from 63% for 500 mg dose to 89% for 1000 mg dose. [6] Its plasma terminal elimination half-life is 1.9–2.5 hours, [6] and volume of distribution is roughly 50 L. [134] Protein binding is negligible, except under the conditions of overdose, when it may reach 15–21%. [6]
Robenacoxib, sold under the brand name Onsior, is a nonsteroidal anti-inflammatory drug (NSAID) used in veterinary medicine for the relief of pain and inflammation in cats and dogs. [4][5] It is a COX-2 inhibitor (coxib).
Pregnancy category. The pregnancy category of a medication is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. It does not include any risks conferred by pharmaceutical agents or their metabolites in breast milk.
The first theory suggests feline hyperesthesia syndrome is a behavioural disorder, which is caused by either behavioural displacement or stress factors. Stress increases the release of [alpha]-melanocyte-stimulating hormone and causes increased grooming and endorphin production. [2][4][5][6] Behavioural displacement would occur when a cat ...
Feline cystitis means "inflammation of the bladder in cats". The term idiopathic means unknown cause; however, certain behaviours have been known to aggravate the illness once it has been initiated. It can affect both males and females of any breed of cat. It is more commonly found in female cats; however, when males do exhibit cystitis, it is ...
Paracetamol (acetaminophen) is generally not considered an NSAID because it has only minor anti-inflammatory activity. Paracetamol treats pain mainly by blocking COX-2 and inhibiting endocannabinoid reuptake almost exclusively within the brain, and only minimally in the rest of the body. [15] [16]