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Beyond adverse effects from the herb itself, "adulteration, inappropriate formulation, or lack of understanding of plant and drug interactions have led to adverse reactions that are sometimes life threatening or lethal." [3]
The key structural elements that enable phytoestrogens to bind with high affinity to estrogen receptors and display estradiol-like effects are: [2] The phenolic ring that is indispensable for binding to estrogen receptor; The ring of isoflavones mimicking a ring of estrogens at the receptors binding site
Phytoprogestogens, also known as phytoprogestins, are phytochemicals (that is, naturally occurring, plant-derived chemicals) with progestogenic effects. [1] [2]Relative to their phytoestrogen counterparts, phytoprogestogens are rare. [1]
With continued use, steroids have dangerous side effects which include, but are not limited to: high blood pressure, diabetes, weight gain, osteoporosis, stomach ulcers, adrenal insufficiency ...
The side effects of cyproterone acetate (CPA), a steroidal antiandrogen and progestin, including its frequent and rare side effects, have been studied and characterized.It is generally well-tolerated and has a mild side-effect profile, regardless of dosage, when it used as a progestin or antiandrogen in combination with an estrogen such as ethinylestradiol or estradiol valerate in women.
An estrogen patch may be recommended for women experiencing moderate to severe symptoms of menopause, such as vasomotor symptoms and vaginal atrophy. During menopause, the ovaries stop producing estrogen which causes estrogen levels to fall. The sudden change in estrogen levels may cause vasomotor symptoms, such as hot flashes.