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Nifedipine, sold under the brand name Procardia among others, is a calcium channel blocker medication used to manage angina, high blood pressure, Raynaud's phenomenon, and premature labor. [2] It is one of the treatments of choice for Prinzmetal angina . [ 2 ]
Absorption half-life 1 h, elimination half-life 12 h. Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (C max) to half of C max in the blood plasma.
But is also equivalent to divided by elimination rate half-life /, = /. Thus, = /. This means, for example, that an increase in total clearance results in a decrease in elimination rate half-life, provided distribution volume is constant.
The plasma half-life or half life of elimination is the time required to eliminate 50% of the absorbed dose of a drug from an organism. Or put another way, the time that it takes for the plasma concentration to fall by half from its maximum levels.
In terms of drug half-life, nitrendipine has a half-life of 12–24 hours. [3] The reported side effects include: headache, flushing, edema and palpitations. These side effects can all be attributed to the vasodilation effect of this drug. [3]
Elimination half-life (hrs) 2 [44] Prolonged in congestive heart failure (mean 3.4 hrs) [45] [48] Prolonged in severe kidney failure (4 – 6 hrs) [49] and anephric ...
The mean elimination half-life appears to be 5–10 hours. [13] Riociguat plasma concentrations have been also shown to be quite variable between patients, indicating that for clinical use it is probably necessary to titrate the drug specifically for each individual.
Phenytoin elimination kinetics show mixed-order, non-linear elimination behaviour at therapeutic concentrations. Where phenytoin is at low concentration it is cleared by first order kinetics, and at high concentrations by zero order kinetics. A small increase in dose may lead to a large increase in drug concentration as elimination becomes ...