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Rescue treatment involves acute symptomatic control with medication. [4] Recommendations for rescue therapy of migraine include: (1) migraine-specific agents such as triptans, CGRP antagonists, or ditans for patients with severe headaches or for headaches that respond poorly to analgesics, (2) non-oral (typically nasal or injection) route of administration for patients with vomiting, (3) avoid ...
Atogepant demonstrated efficacy in two phase 3 trials (ADVANCE and PROGRESS) by significantly reducing monthly migraine days, acute medication use, and improving quality of life in patients with episodic and chronic migraine over 12 weeks compared to placebo. [13] Common side effects included nausea, constipation, and fatigue/somnolence.
Memantine, which is used in the treatment of Alzheimer's Disease, is beginning to be used off label for the treatment of migraine. It has not yet been approved by the FDA for the treatment of migraine. Aspirin can be taken daily in low doses such as 80 mg. The blood thinners in ASA have been shown to help some migraineurs, especially those who ...
Chlorpromazine is occasionally used off-label for treatment of severe migraine. [19] [20] It is often, particularly as palliation, used in small doses to reduce nausea by opioid-treated cancer patients and to intensify and prolong the analgesia of the opioids as well. [19] [21] Efficacy has been shown in treatment of symptomatic hypertensive ...
Almotriptan (trade name Axert and others) is a triptan medication discovered and developed by Almirall for the treatment of heavy migraine headache. It was patented in 1992 and approved for medical use in 2000.
Fremanezumab, sold under the brand name Ajovy, is a medication used to prevent migraines in adults. [8] [6] It is given by injection under the skin. [8] [6] The most common side effect is pain and redness at the site of injection. [8] Other side effects include allergic reactions. [8]
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