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Descriptions of human molybdenum deficiency are few. A patient receiving prolonged parenteral nutrition acquired a syndrome described as ‘acquired molybdenum deficiency.’ This syndrome, exacerbated by methionine administration, was characterized by high blood methionine, low blood uric acid , and low urinary uric acid and sulfate ...
A congenital molybdenum cofactor deficiency disease, seen in infants, is an inability to synthesize molybdenum cofactor, the heterocyclic molecule discussed above that binds molybdenum at the active site in all known human enzymes that use molybdenum. The resulting deficiency results in high levels of sulfite and urate, and neurological damage.
Molybdenum cofactor deficiency is a rare human disease in which the absence of molybdopterin – and consequently its molybdenum complex, commonly called molybdenum cofactor – leads to accumulation of toxic levels of sulphite and neurological damage.
A congenital molybdenum cofactor deficiency disease, seen in infants, is an inability to synthesize molybdenum cofactor, the heterocyclic molecule discussed above that binds molybdenum at the active site in all known human enzymes that use molybdenum. The resulting deficiency results in high levels of sulfite and urate, and neurological damage.
For example, legumes host molybdenum-containing nitrogenase, but animals do not. Many animals rely on hemoglobin (Fe) for oxygen transport, but plants do not. Fertilizers are often tailored to address mineral deficiencies in particular soils. Examples include molybdenum deficiency, manganese deficiency, zinc deficiency, and so on.
Molybdenum cofactor biosynthesis protein 1 is a protein that in humans and other animals, fungi, and cellular slime molds, is encoded by the MOCS1 gene. [5] [6] [7] [8]Both copies of this gene are defective in patients with molybdenum cofactor deficiency, type A. [8]
Molybdenum cofactor synthesis protein 2A and molybdenum cofactor synthesis protein 2B are a pair of proteins that in humans are encoded from the same MOCS2 gene. [ 5 ] [ 6 ] [ 7 ] These two proteins dimerize to form molybdopterin synthase .
For human-specific nutrients, see Mineral (nutrient). Minerals. Calcium [3] ... Molybdenum; Cobalt (as a component of vitamin B 12) Fluorine; Iodine [6] Silicon [7]