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Ofloxacin is a quinolone antibiotic useful for the treatment of a number of bacterial infections. [1] When taken by mouth or injection into a vein , these include pneumonia , cellulitis , urinary tract infections , prostatitis , plague , and certain types of infectious diarrhea .
Common antibiotic ear drops for treating otitis externa include: [14] Polymyxin B, neomycin and hydrocortisone; apply 3-4 drops to the affected ear 4 times daily; Ofloxacin; apply 5 drops to the affected ear twice daily; Ciprofloxacin with hydrocortisone; apply 3 drops to the affected ear twice daily
Acetic acid ear drops may be used as a preventive measure. [3] Treatment of acute cases is typically with antibiotic drops, such as ofloxacin or acetic acid. [2] [3] Steroid drops may be used in addition to antibiotics. [2] Pain medications such as ibuprofen may be used for the pain. [2]
Fluoroquinolones have varying specificity for cytochrome P450, so may have interactions with drugs cleared by those enzymes; the order from most P450-inhibitory to least, is enoxacin > ciprofloxacin > norfloxacin > ofloxacin, levofloxacin, trovafloxacin, gatifloxacin, moxifloxacin. [50]
Eye, ear or bladder infections; usually applied directly to the eye or inhaled into the lungs; rarely given by injection, although the use of intravenous colistin is experiencing a resurgence due to the emergence of multi drug resistant organisms. Kidney and nerve damage (when given by injection)
Otomycosis commonly worsens from overuse of antibacterial ear drops, which should never be used for more than 7 days. In such cases the fungus is an opportunist that results from antibacterial suppression of the normal bacterial flora, combined with the steroid the drops also contain. [4]
Ear drops are commonly used to treat swimmer's ear. Ear instillation is the process of introducing otic medication or other liquids into the ear canal. Proper care is needed in delivering such liquids.
[1] [35] Where the site of infection is easily accessed, antibiotics may be given topically in the form of eye drops onto the conjunctiva for conjunctivitis or ear drops for ear infections and acute cases of swimmer's ear. Topical use is also one of the treatment options for some skin conditions including acne and cellulitis. [40]