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A potassium channel opener is a type of drug which facilitates ion transmission through potassium channels. Examples. Some examples include:
Potassium channel blockers exhibit reverse use-dependent prolongation of the action potential duration. Reverse use dependence is the effect where the efficacy of the drug is reduced after repeated use of the tissue. [11] This contrasts with (ordinary) use dependence, where the efficacy of the drug is increased after repeated use of the tissue.
Potassium-sparing diuretics or antikaliuretics [1] refer to drugs that cause diuresis without causing potassium loss in the urine. [2] They are typically used as an adjunct in management of hypertension , cirrhosis , and congestive heart failure . [ 3 ]
Amiloride was the only drug in the screen that was capable of causing the excretion of sodium (natriuresis) without a concomitant urinary excretion of potassium (kaliuresis). [27] Thousands of amiloride analogues have been studied since its initial discovery, which have been used to study the effects of sodium transporters.
Drug interactions include lithium, agents increasing serum levels of potassium, nonsteroidal anti-inflammatory drugs (NSAIDs), antidiabetic drugs, cholestyramine, and colestipol. [ 1 ] Mechanisms
Loop diuretics are 90% bonded to proteins and are secreted into the proximal convoluted tubule through organic anion transporter 1 (OAT-1), OAT-2, and ABCC4.Loop diuretics act on the Na +-K +-2Cl − symporter (NKCC2) in the thick ascending limb of the loop of Henle to inhibit sodium, chloride and potassium reabsorption.
Potassium chloride, also known as potassium salt, is used as a medication to treat and prevent low blood potassium. [2] Low blood potassium may occur due to vomiting, diarrhea, or certain medications. [3] The concentrated version should be diluted before use. [2] It is given by slow injection into a vein or by mouth. [4]
Retigabine works primarily as a potassium channel opener—that is, by activating a certain family of voltage-gated potassium channels in the brain. [5] [6] [7] This mechanism of action is unique among antiepileptic drugs, and may hold promise for the treatment of other neurologic conditions, including tinnitus, migraine and neuropathic pain ...