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Secretin is a hormone that regulates water homeostasis throughout the body and influences the environment of the duodenum by regulating secretions in the stomach, pancreas, and liver. It is a peptide hormone produced in the S cells of the duodenum, which are located in the intestinal glands. [5] In humans, the secretin peptide is encoded by the ...
Secretion is the movement of material from one point to another, such as a secreted chemical substance from a cell or gland. In contrast, excretion is the removal of certain substances or waste products from a cell or organism. The classical mechanism of cell secretion is via secretory portals at the plasma membrane called porosomes. [1]
The Secretin family are peptides that act as local hormones which regulate activity of G-protein coupled receptors. Most often found in the pancreas and the intestines. Secretin was discovered in 1902 by E. H. Starling. It was later linked to chemical regulation and was the first substance to be deemed a hormone. [8] Secretin; Glucagon ...
S cells are cells which release secretin, found in the jejunum and duodenum. [1] They are stimulated by a drop in pH to 4 or below in the small intestine 's lumen. The released secretin will increase the secretion of bicarbonate (HCO 3 − ) into the lumen, via the pancreas .
Later studies showed that most of the gut peptides, such as secretin, cholecystokinin or substance P, were found to play a role of neurotransmitters and neuromodulators in the central and peripheral nervous systems. [1] Enteroendocrine cells do not form glands but are spread throughout the digestive tract.
Other members of the structurally similar group include secretin, gastric inhibitory peptide, vasoactive intestinal peptide, prealbumin, peptide HI-27, and growth hormone releasing factor. One hormone, glucagon, is fully conserved in all mammalian species in which it has been studied. [4]
The secretin receptor is a protein that in humans is encoded by the SCTR gene. This protein is a G protein-coupled receptor which binds secretin and is the leading member ( i.e. , first cloned) of the secretin receptor family , also called class B GPCR subfamily.
This functions to increase cell wall extensibility. The outer part of the primary cell wall of the plant epidermis is usually impregnated with cutin and wax, forming a permeability barrier known as the plant cuticle. Secondary cell walls contain a wide range of additional compounds that modify their mechanical properties and permeability.