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Current recommendations for the treatment of leprosy suggest multidrug regimens rather than monotherapy because such a regimen has proven to be more effective, delays the emergence of resistance, prevents relapse, and shortens the duration of therapy. Established agents used in the treatment of leprosy are dapsone, clofazimine, and rifampicin ...
Clofazimine was originally intended as an anti-tuberculosis drug but proved ineffective. In 1959, a researcher named Y. T. Chang identified its effectiveness against leprosy. After clinical trials in Nigeria and elsewhere during the 1960s, Swiss pharmaceutical company Novartis launched the product in 1969 under the brand name Lamprene.
In 1957 Price was appointed to the Colonial Medical Service of the then Eastern Region, Nigeria later Biafra. [17] He worked in orthopaedic surgery on the rehabilitation of leprosy patients. He was based first at Uzuakoli leprosarium and Research centre, [18] where Frank Davey [19] was working on the new Dapsone treatment of leprosy.
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Leprosy has historically been associated with social stigma, which continues to be a barrier to self-reporting and early treatment. [4] Leprosy is classified as a neglected tropical disease. [21] World Leprosy Day was started in 1954 to draw awareness to those affected by leprosy. [22] [4] The study of leprosy and its treatment is known as ...
They concluded that a single dose of a combination of rifampicin, ofloxacin and minocycline is an acceptable and cost-effective alternative regimen for the treatment of single-lesion paucibacillary leprosy and the duration of the standard regimen for multibacillary leprosy could be shortened to 12 months.
The National Institute for Pharmaceutical Research and Development (NIPRD) is a Nigerian institution charged with developing drugs, biological products, and pharmaceutical raw materials, conducting quality-assurance tests, research for locally manufactured medicines and constituting guidelines for their production.
According to recent figures from the WHO, 208,619 new cases of leprosy were reported in 2018 from 127 countries. [58] It is most prevalent in India (69% of cases), Brazil, Indonesia, Nigeria, the Democratic Republic of the Congo, Madagascar, and East Africa from Mozambique to Ethiopia, with the highest relative incidence in India, Brazil, and ...