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Medicinal or pharmaceutical chemistry is a scientific discipline at the intersection of chemistry and pharmacy involved with designing and developing pharmaceutical drugs. Medicinal chemistry involves the identification, synthesis and development of new chemical entities suitable for therapeutic use.
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Pharmacognosy is the study of crude drugs obtained from medicinal plants, animals, fungi, and other natural sources. [1] The American Society of Pharmacognosy defines pharmacognosy as "the study of the physical, chemical, biochemical , and biological properties of drugs, drug substances, or potential drugs or drug substances of natural origin ...
Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.
Robert Vince was born in Auburn, New York.After graduating with a Bachelor of Science in Pharmacy in 1962, Vince joined the research group of Prof Howard J. Schaeffer at SUNY Buffalo in New York, where he obtained his doctoral degree in medicinal chemistry.
Authors can elect to have accepted articles published as open access. [1] According to the Journal Citation Reports, the journal has a 2014 impact factor of 2.495, ranking it 27th out of 59 journals in the category "Chemistry, Medicinal" [2] and 163 out of 289 journals in the category "Biochemistry & Molecular Biology". [3]
Description: Selected articles: [citation needed] "Supramolecular Medicinal Chemistry: Mixed-Ligand Coordination Complexes".Mol. Pharmaceutics, 2007, 4 (3), pp 373–385;"Pharmaceutical co-crystals".Journal of Pharmaceutical Sciences, 2006, 95 (3), pp 499–516;"Crystal engineering of pharmaceutical co-crystals from polymorphic active ...
[1] Formulation studies then consider such factors as particle size, polymorphism, pH, and solubility, as all of these can influence bioavailability and hence the activity of a drug. The drug must be combined with inactive ingredients by a method that ensures that the quantity of drug present is consistent in each dosage unit e.g. each tablet ...