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Melatonin, also known as N -acetyl-5-methoxytryptamine, is a substituted tryptamine and a derivative of serotonin (5-hydroxytryptamine). It is structurally related to N-acetylserotonin (normelatonin; N -acetyl-5-hydroxytryptamine), which is the chemical intermediate between serotonin and melatonin in the body.
In humans, ~30 μg of melatonin is produced daily and 80% of the total amount is produced in the night. The plasma maximum concentration of melatonin at night are 80–120 pg/mL and the concentrations during the day are between 10–20 pg/mL.
Ashwagandha is an adaptogen, an herb that helps regulate the stress hormone cortisol. It comes from a shrub that grows in Africa and Asia, but you can often buy it as a capsule, powder, or tea ...
Side effects of melatonin may include sleep disturbance, nightmares, daytime sleepiness, and depression, though the current tendency to use lower doses has decreased such complaints. Large doses of melatonin can even be counterproductive: Lewy et al. [ 48 ] provide support to "the idea that too much melatonin may spill over onto the wrong zone ...
Initially, people with insomnia experience fatigue, low energy, difficulty concentrating and impaired memory. Some other short-term effects include: Mood disturbances, such as irritability or ...
On those nights (or weeks) when insomnia takes hold, a melatonin supplement can help you wind down and get a good night's sleep. Not only do the best melatonin supplements contain an appropriate ...