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The 3α-hydroxysteroid dehydrogenase (3α-HSD) enzyme is induced by certain (SSRIs), including fluoxetine, fluvoxamine, sertraline, and paroxetine, as well as by certain other antidepressants like venlafaxine and mirtazapine, and these antidepressants have been found to increase inhibitory neurosteroid levels.
[2] [3] [4] Contrarily, 3α-HSD is induced to varying extents by certain selective serotonin reuptake inhibitors (SSRIs), including fluoxetine, fluvoxamine, sertraline, and paroxetine, as well as by certain other antidepressants like venlafaxine and mirtazapine, and these antidepressants have been found to increase inhibitory neurosteroid levels.
The mechanism by which neurosteroid GABA A receptor PAMs like brexanolone have antidepressant effects is unknown. [54] Other GABA A receptor PAMs, such as benzodiazepines, are not thought of as antidepressants and have no proven efficacy, [54] although alprazolam has historically been prescribed for depression.
The medication is a formulation of a neurosteroid called allopregnanolone and a “cousin” to the IV infusion brexanolone, which was approved by the FDA in 2019. ... Other antidepressants and ...
Most antidepressants aim for the same target: the monoamine system. They work by raising levels of one or more of the monoamine neurotransmitters in the brain that are involved in mood—serotonin ...
Escitalopram, a less recognizable term, is the generic name for this common prescription antidepressant. Lexapro is one of the most recognizable drug names of our modern era. Escitalopram, a less ...
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