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  2. Myeloproliferative neoplasm - Wikipedia

    en.wikipedia.org/wiki/Myeloproliferative_neoplasm

    Tyrosine kinase inhibitors like imatinib have improved the prognosis of CML patients to near-normal life expectancy. [14] Recently, a JAK2 inhibitor, namely ruxolitinib, has been approved for use in primary myelofibrosis. [15] Trials of these inhibitors are in progress for the treatment of the other myeloproliferative neoplasms.

  3. Chronic myelogenous leukemia - Wikipedia

    en.wikipedia.org/wiki/Chronic_myelogenous_leukemia

    It is a type of myeloproliferative neoplasm associated with a characteristic chromosomal translocation called the Philadelphia chromosome. CML is largely treated with targeted drugs called tyrosine-kinase inhibitors (TKIs) which have led to dramatically improved long-term survival rates since 2001. These drugs have revolutionized treatment of ...

  4. Essential thrombocythemia - Wikipedia

    en.wikipedia.org/wiki/Essential_thrombocythemia

    In hematology, essential thrombocythemia (ET) is a rare chronic blood cancer (myeloproliferative neoplasm) characterised by the overproduction of platelets (thrombocytes) by megakaryocytes in the bone marrow. [3] It may, albeit rarely, develop into acute myeloid leukemia or myelofibrosis. [3]

  5. Acute myeloid leukemia - Wikipedia

    en.wikipedia.org/wiki/Acute_myeloid_leukemia

    The five-year survival rate is about 35% in people under 60 years old and 10% in people ... and less commonly myeloproliferative neoplasms (MPN), can evolve into ...

  6. Chronic myelomonocytic leukemia - Wikipedia

    en.wikipedia.org/wiki/Chronic_myelomonocytic...

    Due to the scoring system being developed for MDS, the more myeloproliferative cases of CMML (WBC >13x10 9) are excluded from the scoring system. Although the IPSS scoring system is used clinically, there is a high variability in each group. For this reason, new modalities for assessing prognosis in MDS (and CMML) are being developed. [12] [24]

  7. Acute megakaryoblastic leukemia - Wikipedia

    en.wikipedia.org/wiki/Acute_megakaryoblastic...

    The 5-year event free survival, disease-free survival, and overall survival rate in the phase 3 clinical study in DS-AMKL were 79, 89, 84 percent, respectively. [13] Other studies that use a treatment regimen similar to that used in the phase 3 clinical study report overall survival rates of ~80% [ 7 ] and long-term survivals of 74-91%. [ 9 ]

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