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Lacosamide has a K d value just under 5 μM and a B max of about 200 pM/mg. [34] The volume of distribution (V d) of lacosamide in plasma is 0.6 L/kg, which is close to the total volume of water. Lacosamide is ampiphilic and is thus hydrophilic while also lipophilic enough to cross the blood-brain barrier .
Amoco (/ ˈ æ m ə k oʊ / AM-ə-koh) is a brand of fuel stations operating in the United States and owned by British conglomerate BP since 1998. The Amoco Corporation was an American chemical and oil company, founded by Standard Oil Company in 1889 around a refinery in Whiting, Indiana, and was officially the Standard Oil Company of Indiana until 1985.
Although it has been estimated that a single 300 mg dose of moclobemide inhibits 80% of monoamine oxidase-A (MAO-A) and 20-30% of MAO-B, [100] studies evaluating brain occupancy of MAO-A enzymes have shown dosages of 600 mg to only inhibit 74% of MAO-A enzymes [101] and dosages in the 900–1200 mg range to inhibit slightly less MAO-A than ...
An Audi R10 TDI LMP race car, fueled on Shell V-Power Diesel. V-Power Diesel is Shell's version of an enhanced diesel fuel, similar to BP's 'Ultimate Diesel'. Like BP Ultimate Diesel, Shell V-Power Diesel is designed for modern compression-ignition diesel engines, to facilitate enhanced engine performance along with increased engine protection, for more consistent operation and engine longevity.
What Was Sildenafil Used for Originally? Since 1998, the Pfizer-created drug sildenafil citrate has been a reliable treatment for the management of ED.
Ocrelizumab, sold under the brand name Ocrevus, is a medication used for the treatment of multiple sclerosis.It is a humanized anti-CD20 monoclonal antibody. [8] It targets CD20 marker on B lymphocytes and is an immunosuppressive drug. [10]
[24] [34] [138] In the United States as of July 2019 the wholesale/pharmacy cost for generic pregabalin is US$0.17–0.22 per 150 mg capsule. [ 140 ] From 2008 until 2018, Pfizer engaged in extensive direct-to-consumer advertising campaigns to promote its branded product Lyrica for fibromyalgia and diabetic nerve pain indications.
Temgicoluril (INN Tooltip International Nonproprietary Name), [2] also known as tetramethylglycoluril and sold under the brand names Adaptol and Mebicar, is an anxiolytic medication produced by Latvian pharmaceutical company Olainfarm and sold in Latvia and Russia.