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Merkel cells, also known as Merkel–Ranvier cells or tactile epithelial cells, are oval-shaped mechanoreceptors essential for light touch sensation and found in the skin of vertebrates. They are abundant in highly sensitive skin like that of the fingertips in humans , and make synaptic contacts with somatosensory afferent nerve fibers .
The Merkel cell expresses the PIEZO2 mechanosensitive ion channels; mechanical activation of the channel causes depolarisation of the Merkel cell and consequent release of [1] serotonin into a synapse with the associated nerve ending, to also depolarise the later. [3] The nerve ending meanwhile expresses an unknown mechanosensitive channel. [1]
The Slowly Adapting type 1 (SA1) mechanoreceptor, with the Merkel corpuscle end-organ (also known as Merkel discs) detect sustained pressure and underlies the perception of form and roughness on the skin. [1] They have small receptive fields and produce sustained responses to static stimulation. [citation needed]
Cancer Research UK has recently warned that skin cancer cases are set to rise by half by 2040
Merkel cell carcinoma (also known as Merkel cell skin cancer) is a rare type of cancer where malignant cells form in the skin, according to the National Cancer Institute (NCI).
The density of tactile corpuscles, a type of mechanoreceptor that detects low-frequency vibrations, is greater in smaller fingers; [37] the same may hold for Merkel cells, which detect the static indentations important for fine spatial acuity. [36] Among children of the same age, those with smaller fingers also tend to have better tactile ...
Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer occurring in about three people per million members of the population. [1] It is also known as cutaneous APUDoma, primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, and trabecular carcinoma of the skin. [2]
Singer-songwriter Jimmy Buffett, who died September 1, had Merkel cell carcinoma, a skin cancer that’s diagnosed in fewer than 3,000 people in the US every year.