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A meta-analysis of short-term randomized controlled trials has shown similar efficacy on glycemic control between empagliflozin 10mg and 25mg in people with type 2 diabetes. While there may be a higher reduction in HbA1c with higher doses, this difference is more clinically significant when the patients' baseline HbA1c is ≥ 8.5%.
In contrast with other anti-hyperglycemic diabetes medications, SGLT2 inhibitors enhance, rather than suppress, gluconeogenesis and ketogenesis. [51] Because SGLT2 inhibitors activate sirtuin 1 (and thus PGC-1α and FGF21), they are more cardioprotective than the other medications used to treat diabetes. [51]
In one corner, we’ve got Mounjaro, and in the other, Ozempic. They’re both once-a-week injectable drugs designed to help patients with type 2 diabetes manage blood sugar.
Ozempic is an FDA-approved medication for people who have type 2 diabetes. It’s often prescribed “off-label” for weight loss — when a drug is prescribed for something it’s not approved for.
Tirzepatide [12] is an antidiabetic medication used for the treatment of type 2 diabetes [9] [13] [14] [15] and for weight loss. [10] [16] Tirzepatide is administered via subcutaneous injections (under the skin).
Ozempic, Wegovy, Mounjaro and similar medications for Type 2 diabetes and weight loss may help with other conditions as well. Heart disease, kidney health, infertility and even addictive impulses ...
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