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Well, there’s no magic time, but you should take metformin at the same time each day and with food to avoid gastrointestinal side effects. If you’re taking extended-release metformin tablets ...
Common adverse effects include diarrhea, nausea, and abdominal pain. [16] It has a small risk of causing low blood sugar. [16] High blood lactic acid level is a concern if the medication is used in overly large doses or prescribed in people with severe kidney problems. [23] [24] Metformin is a biguanide anti-hyperglycemic agent. [16]
If metformin is causing GI side effects such as diarrhea or bloating, first try reducing the dose and taking it just once a day instead of twice a day, Dr. Gupta suggests.
Metformin is a prescription medication used to treat high blood sugar in those with type 2 diabetes who are resistant to the effects of insulin. It’s in a class of drugs known as biguanides.
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Generally speaking, GLP-1s, GIP/GLP-1s, and metformin are considered safe and effective when used as prescribed. That said, no medication is without side effects.