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Muir–Torre syndrome is a rare hereditary, autosomal dominant cancer syndrome [1]: 663 that is thought to be a subtype of HNPCC (Lynch syndrome). Individuals are prone to develop cancers of the colon, genitourinary tract, and skin lesions, such as keratoacanthomas and sebaceous tumors .
Hereditary nonpolyposis colorectal cancer (HNPCC) is a hereditary predisposition to colon cancer.. HNPCC includes (and was once synonymous with) [1] Lynch syndrome, an autosomal dominant genetic condition that is associated with a high risk of colon cancer, endometrial cancer (second most common), ovary, stomach, small intestine, hepatobiliary tract, upper urinary tract, brain, and skin. [2]
MSI tumors in 15% of sporadic colorectal cancer result from the hypermethylation of the MLH 1 gene promoter, whereas MSI tumors in Lynch syndrome are caused by germline mutations in MLH1, MSH2, MSH6, and PMS2. [3] MSI has been evident in the cause of sebaceous carcinomas. Sebaceous carcinomas are a subset of a larger pathology, Muir-Torre ...
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Some women using oral birth control reported getting pregnant while on weight loss medications, and that isn't a coincidence—but, Dr. Sekhon notes, it also only applies to two specific weight ...
Inherited mutations in MCM8 and MCM9 can cause a chromosomal instability syndrome characterized by ovarian failure. [ 2 ] [ 3 ] The germline MCM8-MCM9 protein complex is most likely required for the resolution of double-strand breaks that occur during homologous recombination in the pachytene stage of meiosis I. [ 2 ]
For women ages 40–44, the birth rate increased 4 percent between 2021 and 2022 (and has been continually inching up since 1985), while the birth rate for women ages 45 and over increased 12 percent.
The actor and standup comedian received a Cushing’s syndrome diagnosis in 2024. The condition may cause significant facial swelling, colloquially termed “moon face.” Facial puffiness can ...