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Though distinct from clonal selection, Ehrlich's idea was a selection theory far more accurate than the instructive theories that dominated immunology in the next decades. In 1955, Danish immunologist Niels Jerne put forward a hypothesis that there is already a vast array of soluble antibodies in the serum prior to any infection.
Human cloning is banned by the Presidential Decree 200/97 of 7 March 1997. [48] Australia: Illegal [50] [49] Legal [51] Australia has prohibited human cloning, [52] though as of December 2006, a bill legalizing therapeutic cloning and the creation of human embryos for stem cell research passed the House of Representatives. Within certain ...
This idea is known as clonal selection theory. At the time, many leading scientists including Linus Pauling and James Watson completely rejected the idea, but repeated experimentation intended to disprove the theory actually served to build up a large body of evidence supporting Burnet and Jerne's theory. [1]
The theory is now sometimes known as Burnet's clonal selection theory, [113] which overlooks the contributions of Ehrlich, Jerne, Talmage, and the contributions of Lederberg, who conceptualised the genetics of clonal selection. [114] Burnet's work on graft-versus-host was in collaboration with Lone Simonsen between 1960 and 1962.
The goal is not to create cloned human beings (called "reproductive cloning"), but rather to harvest stem cells that can be used to study human development and to potentially treat disease. While a clonal human blastocyst has been created, stem cell lines are yet to be isolated from a clonal source. [14]
A hypothetical HIV vaccine concept based on immune network theory has been described. [23] The vaccine concept was based on a network theory resolution of the Oudin-Cazenave paradox. [24] This is a phenomenon that makes no sense in the context of clonal selection, without taking idiotypic network interactions into account.
Edelman reasoned that the N-CAM molecule which is used for self-self recognition and adherence between neurons in the nervous system gave rise to their evolutionary descendants, the antibodies, who evolved self-nonself recognition via antigen-adherence at the origins of the vertebrate antibody-based immune system. If clonal selection was the ...
1957 – Clonal selection theory (Frank Macfarlane Burnet) 1957 – Discovery of interferon by Alick Isaacs and Jean Lindenmann [10] 1958–1962 – Discovery of human leukocyte antigens (Jean Dausset and others) 1959–1962 – Discovery of antibody structure (independently elucidated by Gerald Edelman and Rodney Porter)