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Macrophages are found in essentially all tissues, [4] where they patrol for potential pathogens by amoeboid movement. They take various forms (with various names) throughout the body (e.g., histiocytes, Kupffer cells, alveolar macrophages, microglia, and others), but all are part of the mononuclear phagocyte system.
The cells are primarily monocytes and macrophages, and they accumulate in lymph nodes and the spleen. The Kupffer cells of the liver and tissue histiocytes are also part of the MPS. The mononuclear phagocyte system and the monocyte macrophage system refer to two different entities, often mistakenly understood as one. [citation needed]
General macrophage targets [10] [8] Kupffer cell: Monocyte: Macrophage: Stellate macrophages; Kupffer–Browicz cells; Liver macrophage; Macrophagocytus stellatus; 20-21 Foreign debris; General macrophage targets [11] [8] Alveolar macrophage: Monocyte: Macrophage: Pulmonary macrophage; Dust cell; 20-21 Carbon debris from lungs; General ...
They circulate through the body and enter various organs, where they undergo differentiation into histiocytes, which are part of the mononuclear phagocytic system (MPS). However, the term histiocyte has been used for multiple purposes in the past, and some cells called "histocytes" do not appear to derive from monocytic-macrophage lines. [ 3 ]
Macrophages are found throughout the body in almost all tissues and organs (e.g., microglial cells in the brain and alveolar macrophages in the lungs), where they silently lie in wait. A macrophage's location can determine its size and appearance. Macrophages cause inflammation through the production of interleukin-1, interleukin-6, and TNF ...
The HuBMAP project has organized 1551 different samples in 17 collections, each dedicated to a different system. However, this project still only mapped about 31 of the human bodies' 70 organs. Their datasets and visualisations place great emphasis on biomarkers and location in the body, but less on cell development and how cells can change ...
Pages in category "Macrophages" The following 23 pages are in this category, out of 23 total. This list may not reflect recent changes. ...
During the years that followed after Aschoff had originated the concept of RES, research on macrophages and their role as phagocytes steadily increased, and in 1960 the concept of the mononuclear phagocyte system was proposed to denote all cells identified as macrophages. The cells of MPS, by way of their common functional signature as ...