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An orexigenic, or appetite stimulant, is a drug, hormone, or compound that increases appetite and may induce hyperphagia.This can be a medication or a naturally occurring neuropeptide hormone, such as ghrelin, orexin or neuropeptide Y, [1] [2] which increases hunger and therefore enhances food consumption.
Sermorelin acetate (INN Tooltip International Nonproprietary Name; brand names Geref, Gerel), also known as GHRH (1-29), is a peptide analogue of growth hormone-releasing hormone (GHRH) which is used as a diagnostic agent to assess growth hormone (GH) secretion for the purpose of diagnosing growth hormone deficiency.
Ghrelin (/ ˈ ɡ r ɛ l ɪ n /; or lenomorelin, INN) is a hormone primarily produced by enteroendocrine cells of the gastrointestinal tract, especially the stomach, [5] [6] and is often called a "hunger hormone" because it increases the drive to eat. [6]
Ibutamoren (INN Tooltip International Nonproprietary Name) (developmental code names MK-677, MK-0677, LUM-201, L-163,191; former tentative brand name Oratrope) is a potent, long-acting, orally-active, selective, and non-peptide agonist of the ghrelin receptor and a growth hormone secretagogue, mimicking the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin.
Over the six-month observation period, researchers observed that participants not only lost weight, about 7% on average, but also showed a nearly 50% drop in fasting ghrelin levels.
Preclinical research has shown that this drug prevented weight gain with positive pharmacological and safety profiles. Additionally, ghrelin O-acyl transferase inhibition has been used in clinical trials in the United Kingdom in studying appetite regulation of post-surgical bariatric patients. The study measured, among other things, the effect ...
Ghrelin is a hormone in the body that regulates hunger and appetite. People with higher levels of ghrelin generally have a harder time losing weight. Past studies have shown that exercise may help ...
Examorelin (developmental code names EP-23905, MF-6003), also known as hexarelin, is a potent, synthetic, peptidic, orally-active, centrally-penetrant, and highly selective agonist of the ghrelin/growth hormone secretagogue receptor (GHSR) and a growth hormone secretagogue which was developed by Mediolanum Farmaceutici.