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Apixaban is a highly selective, orally bioavailable, and reversible direct inhibitor of free and clot-bound factor Xa. Factor Xa catalyzes the conversion of prothrombin to thrombin, the final enzyme in the coagulation cascade that is responsible for fibrin clot formation. [ 28 ]
The p-methoxy group of apixaban connects to S1 pocket of FXa but does not appear to have any interaction with any residues in this region of FXa. The pyrazole N-2 nitrogen atom of apixaban interacts with Gln-192 and the carbonyl oxygen interacts with Gly-216. The phenyl lactam group of apixaban is positioned between Tyr-99 and Phe-174 and due ...
Verapamil is a class-IV antiarrhythmic and more effective than digoxin in controlling ventricular rate. [19] Verapamil is not listed as a first line antihypertensive agent by the guidelines provided by JAMA in JNC-8. [20] However, it may be used to treat hypertension if patient has co-morbid atrial fibrillation or other types of arrhythmia. [17 ...
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The Windows version allows annotating and saving unfinished PDF forms, FDF import/export, converting to text, highlighting, and drawing. Until version 9.7.2 Foxit Reader had PDF creation features, including a "Foxit PDF Printer" for Windows, allowing all programs to "print" output to PDF; they were removed in May 2020 from later versions. [5]
Universal Document Converter is a virtual printer and PDF creator for Microsoft Windows developed by fCoder Group. It can create PDF documents (as raster images or searchable text) and files in graphic formats JPEG, TIFF, PNG, GIF, PCX, DCX and BMP. [3] It can create graphic or PDF files from any document that can be printed.
Skeletal formula of verapamil. Phenylalkylamine calcium channel blockers are relatively selective for myocardium, reduce myocardial oxygen demand and reverse coronary vasospasm, and are often used to treat angina.
A good stand-alone spell checker for English Wikipedia pages is Inspyder InSite. (The free version is good enough for fixing Wikipedia articles.) The macOS universal spell checker is available in Wikipedia's "edit this page" mode while using Safari and in theory any other Cocoa-based browser.