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Reference-based approaches rely on the availability of accurate references to estimate cell proportions. The discrepancy between the biology of the samples underlying the references and the samples for which the cell proportions are being estimated could introduce bias in estimated cell proportions. [ 41 ]
Cell-based models are mathematical models that represent biological cells as discrete entities. Within the field of computational biology they are often simply called agent-based models [1] of which they are a specific application and they are used for simulating the biomechanics of multicellular structures such as tissues. to study the influence of these behaviors on how tissues are organised ...
A cell type is a classification used to identify cells that share morphological or phenotypical features. [1] A multicellular organism may contain cells of a number of widely differing and specialized cell types, such as muscle cells and skin cells, that differ both in appearance and function yet have identical genomic sequences.
Cellular extensions also known as cytoplasmic protrusions and cytoplasmic processes are those structures that project from different cells, in the body, or in other organisms. Many of the extensions are cytoplasmic protrusions such as the axon and dendrite of a neuron, known also as cytoplasmic processes. Different glial cells project ...
The Human Cell Atlas project, which started in 2016, had as one of its goals to "catalog all cell types (for example, immune cells or brain cells) and sub-types in the human body". [13] By 2018, the Human Cell Atlas description based the project on the assumption that "our characterization of the hundreds of types and subtypes of cells in the ...
They have recently produced a generic eukaryotic cell cycle model which can represent a particular eukaryote depending on the values of the parameters, demonstrating that the idiosyncrasies of the individual cell cycles are due to different protein concentrations and affinities, while the underlying mechanisms are conserved (Csikasz-Nagy et al ...
The Human Cell Atlas will catalogue a cell based on several criteria, specifically the cell type, its state, its location in the body, the transitions it undergoes, and its lineage. [8] It will gather data from existing research, and integrate it with data collected in future research projects. [ 3 ]
Transdifferentiation, also known as lineage reprogramming, [1] is the process in which one mature somatic cell is transformed into another mature somatic cell without undergoing an intermediate pluripotent state or progenitor cell type. [2] It is a type of metaplasia, which includes all cell fate switches, including the interconversion of stem ...