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Higher platelet transfusion thresholds have been used in premature neonates, but this has been based on limited evidence. [19] There is now evidence that using a high platelet count threshold (50 x 10 9 /L) increases the risk of death or bleeding compared to a lower platelet count threshold (25 x 10 9 /L) in premature neonates. [20]
In a typical set of rules, a platelet donor must weigh at least 50 kg (110 lb) and have a platelet count of at least 150 x 10 9 /L (150,000 platelets per mm³). [2] One unit has greater than 3×10 11 platelets. Therefore, it takes 2 liters of blood having a platelet count of 150,000/mm³ to produce one unit of platelets.
The single unit policy is helpful in platelet transfusion as there this blood component has a short shelf-life than other components. Assessment after one bag can include assessing clinical bleeding, platelet count looking at the post transfusion increment and/or functional platelet assessments.
Blood doping has been used by athletes to increase ... about 15 million units of blood products were transfused per year in ... 2,243,000 platelet units, and ...
[15] [16] The benefits of single unit transfusion include reduced exposure to blood products. Each unit transfused increases the associated risks of transfusion such as infection, transfusion associated circulatory overload and other side effects. [17] [18] Transfusion of a single unit also encourages less wastage of red blood cells. [19]
Requires data on the platelet increment (PI), the patient's total blood volume (TBV) - estimated using the patient's weight multiplied by 0.075, and the number of platelets transfused (platelet dose) [10] [11] PPR = ((PI x TBV)/PD) x 100 At 1 hour post-transfusion, a PPR < 20% is considered evidence of platelet refractoriness.
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In hematology, thrombocythemia is a condition of high platelet (thrombocyte) count in the blood. Normal count is in the range of 150 × 10 9 to 450 × 10 9 platelets per liter of blood, [1] but investigation is typically only considered if the upper limit exceeds 750 × 10 9 /L.